Sugi Predict

Sugi Predict / Compounds / SCHEMBL24880455

SCHEMBL24880455

SCHEMBL24880455

CC(C)(C)OC(=O)N1CC2(CCN(Cc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)C2)C1

nearest known ligand 0.69

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 18/20 0.69
▸ IKZF3 Q9UKT9 18/20 0.69
▸ TNF P01375 3/20 0.64
▸ IL1B P01584 3/20 0.64
▸ DDB1 Q16531 2/20 0.64
▸ IKZF1 Q13422 1/20 0.64
▸ DRD2 P14416 1/20 0.59
▸ ADRA1D P25100 1/20 0.59
▸ ADRA1A P35348 1/20 0.59
▸ ADRA1B P35368 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2249657 0.90 CRBN (0.76) CRBNIKZF3TNFIL1BDDB1
SCHEMBL24880449 0.85 CRBN (0.77) CRBNIKZF3TNFIL1BDDB1
SCHEMBL2255399 0.84 CRBN (0.65) CRBNIKZF3TNFIL1BDDB1
SCHEMBL2255396 0.84 CRBN (0.65) CRBNIKZF3TNFIL1BDDB1
SCHEMBL30493932 0.84 CRBN (0.65) CRBNIKZF3TNFIL1BDDB1
SCHEMBL2253947 0.84 CRBN (0.64) CRBNIKZF3TNFIL1BDDB1
SCHEMBL2250308 0.84 CRBN (0.64) CRBNIKZF3TNFIL1BDDB1
SCHEMBL29790723 0.84 CRBN (0.64) CRBNIKZF3TNFIL1BDDB1
SCHEMBL2255945 0.84 CRBN (0.74) CRBNIKZF3TNFIL1BDDB1
SCHEMBL16768411 0.83 CRBN (0.65) CRBNIKZF3TNFIL1BDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023280237-A1 SYNTHESIS AND APPLICATION OF PHOSPHATASE DEGRADER 海创药业股份有限公司 2023-01-12 — — WO disclosed
Send feedback