Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 16/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24890781 | 1.00 | HTT (0.56) | HTTGAAPOLBKMT2ACRBN | |
| SCHEMBL21946926 | 0.83 | HTT (0.60) | HTTGAAPOLBKMT2ACRBN | |
| SCHEMBL25843906 | 0.80 | CRBN (0.66) | HTTGAAPOLBKMT2ACRBN | |
| SCHEMBL23594345 | 0.80 | HTT (0.56) | HTTGAAPOLBKMT2ACRBN | |
| SCHEMBL24754153 | 0.77 | CRBN (0.66) | HTTGAAPOLBKMT2ACRBN | |
| SCHEMBL25480065 | 0.75 | CRBN (0.56) | POLBCRBNDDB1 | |
| SCHEMBL6819070 | 0.72 | CRBN (0.71) | HTTGAAPOLBKMT2ACRBN | |
| SCHEMBL19585871 | 0.72 | CRBN (0.71) | HTTGAAPOLBKMT2ACRBN | |
| SCHEMBL23594548 | 0.72 | DDB1 (0.58) | POLBCRBNDDB1 | |
| SCHEMBL24890780 | 0.72 | CRBN (0.55) | HTTPOLBCRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023287928-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK WITH DIMINISHED IMID ACTIVITY | NURIX THERAPEUTICS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |