Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24894502 | 1.00 | PPIA (0.35) | PPIANPSR1OPRD1OPRL1 | |
| SCHEMBL26981402 | 0.95 | NPSR1 (0.34) | PPIANPSR1OPRD1OPRL1 | |
| SCHEMBL24649278 | 0.94 | NPSR1 (0.30) | NPSR1 | |
| SCHEMBL27158501 | 0.86 | PPIA (0.34) | PPIANPSR1OPRD1OPRL1 | |
| SCHEMBL27125926 | 0.83 | — | — | |
| SCHEMBL27158891 | 0.82 | PPIA (0.32) | PPIANPSR1OPRL1 | |
| SCHEMBL27043819 | 0.80 | — | — | |
| SCHEMBL6816556 | 0.77 | NPSR1 (0.41) | PPIANPSR1OPRD1OPRL1 | |
| SCHEMBL31534320 | 0.76 | — | — | |
| SCHEMBL27158933 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024091409-A1 | TRICYCLIC DERIVATIVES AS KRAS INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2024-05-02 | — | — | WO | disclosed |
| WO-2023284730-A1 | ALKYLIDENE DERIVATIVES AS KRAS INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |