Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAICS | P22234 | 4/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | EIF4E | P06730 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.31 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489570 | 1.00 | PAICS (0.35) | PAICSFFAR1FFAR4UTS2RPPARA | |
| SCHEMBL2489569 | 1.00 | PAICS (0.35) | PAICSFFAR1FFAR4UTS2RPPARA | |
| SCHEMBL912865 | 0.95 | PAICS (0.33) | PAICSFFAR1FFAR4UTS2RPPARA | |
| SCHEMBL912863 | 0.95 | PAICS (0.33) | PAICSFFAR1FFAR4UTS2RPPARA | |
| SCHEMBL912866 | 0.95 | PAICS (0.33) | PAICSFFAR1FFAR4UTS2RPPARA | |
| SCHEMBL2488721 | 0.93 | FFAR1 (0.35) | PAICSFFAR1FFAR4PPARAHSP90AB1 | |
| Hydrochloric Acid SCHEMBL544715 | 0.92 | FFAR1 (0.35) | PAICSFFAR1FFAR4PPARAHSP90AB1 | |
| Hydrochloric Acid SCHEMBL544075 | 0.91 | KDM4E (0.37) | PAICSUTS2RHSP90AB1KDRKDM4E | |
| Hydrochloric Acid SCHEMBL545150 | 0.91 | CNR1 (0.35) | PAICSKDRKDM4EMAPTMAPK1 | |
| SCHEMBL2486261 | 0.90 | KDM4E (0.36) | PAICSROCK2KDRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238110-B1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI SA (FR) | 2011-10-26 | — | — | EP | claimed |
| EP-2238110-B1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI SA (FR) | 2011-10-26 | — | — | EP | disclosed |