SCHEMBL24896384

SCHEMBL24896384

Cn1c(C(=O)NC23CC(F)(C2)C3)cc2ccnc(C3CC3)c21

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 1/20 0.37
HPGDS O60760 2/20 0.36
ANO1 Q5XXA6 2/20 0.35
CNR2 P34972 6/20 0.34
CNR1 P21554 3/20 0.32
CHRNA7 P36544 1/20 0.31
SCN10A Q9Y5Y9 1/20 0.31
IDO1 P14902 1/20 0.31
PBK Q96KB5 1/20 0.30
EPHX2 P34913 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24896261 0.84 GRM4 (0.39) GRM4ANO1CNR2CNR1IDO1
SCHEMBL24896350 0.84 GRM4 (0.41) GRM4ANO1CNR2CNR1IDO1
SCHEMBL24896379 0.83 GRM4 (0.38) GRM4ANO1CNR2CNR1
SCHEMBL24896382 0.82 GRM4 (0.35) GRM4HPGDSANO1CNR2
SCHEMBL24896273 0.82 GRM4 (0.38) GRM4ANO1CNR2CNR1
SCHEMBL24896381 0.82 GRM4 (0.38) GRM4HPGDSANO1CNR2CNR1
SCHEMBL24896300 0.82 GRM4 (0.38) GRM4HPGDSANO1CNR2CNR1
SCHEMBL24896274 0.81 GRM4 (0.37) GRM4ANO1CNR2
SCHEMBL24896308 0.78 MCL1 (0.41)
SCHEMBL24896277 0.77 ANO1 (0.40) GRM4ANO1CNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4370207-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS Nido Biosciences, Inc. (US) 2024-05-22 EP disclosed
US-20230039586-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2023-02-09 US disclosed
WO-2023287704-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. (US) 2023-01-19 WO disclosed
WO-2023287704-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. (US) 2023-01-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230039586-A1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 GRM4 461/4885HPGDS 2784/4885ANO1 2433/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.