Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617013 | 1.00 | ATR (0.53) | ATR | |
| SCHEMBL616616 | 1.00 | ATR (0.53) | ATR | |
| SCHEMBL616478 | 0.90 | ATR (0.53) | ATR | |
| SCHEMBL10289496 | 0.90 | ATR (0.53) | ATR | |
| SCHEMBL10255420 | 0.86 | ATR (0.41) | ATR | |
| SCHEMBL10255414 | 0.86 | ATR (0.41) | ATR | |
| SCHEMBL617642 | 0.85 | ATR (0.54) | ATR | |
| SCHEMBL618452 | 0.83 | ATR (0.50) | ATR | |
| SCHEMBL615732 | 0.81 | ATR (0.51) | ATR | |
| SCHEMBL10266120 | 0.81 | ATR (0.51) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370424-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010054398-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-14 | — | — | WO | disclosed |