Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30221487 | 1.00 | EGFR (0.46) | EGFRCDK7CCNHJAK2JAK3 | |
| SCHEMBL24900661 | 0.93 | EGFR (0.49) | EGFRCDK7CCNHKCNH2IGF1R | |
| SCHEMBL30221581 | 0.93 | EGFR (0.49) | EGFRCDK7CCNHKCNH2IGF1R | |
| SCHEMBL24900592 | 0.91 | EGFR (0.46) | EGFRCDK7CCNHJAK2JAK3 | |
| SCHEMBL30221441 | 0.90 | EGFR (0.55) | EGFRKCNH2IGF1R | |
| SCHEMBL24900697 | 0.90 | EGFR (0.55) | EGFRKCNH2IGF1R | |
| SCHEMBL30221325 | 0.88 | EGFR (0.48) | EGFRCDK7CCNHJAK2JAK3 | |
| SCHEMBL24900813 | 0.88 | EGFR (0.48) | EGFRCDK7CCNHJAK2JAK3 | |
| SCHEMBL24900497 | 0.86 | EGFR (0.46) | EGFRCDK7CCNHJAK2JAK3 | |
| SCHEMBL30221604 | 0.86 | EGFR (0.46) | EGFRCDK7CCNHJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023287783-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | ACEA Therapeutics, Inc. (US) | 2023-01-19 | — | — | WO | disclosed |