SCHEMBL2490475

SCHEMBL2490475

NC(=O)c1cnccc1N1CCCCCN1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT3 Q9NTG7 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
CDC7 O00311 3/20 0.41
CDK9 P50750 1/20 0.41
NPC1 O15118 1/20 0.39
HTT P42858 2/20 0.37
CHRM2 P08172 2/20 0.36
CHRM3 P20309 2/20 0.36
CHRM4 P08173 1/20 0.36
PIM1 P11309 2/20 0.36
PIM3 Q86V86 2/20 0.36
PIM2 Q9P1W9 1/20 0.36
MAPT P10636 2/20 0.35
KDM4E B2RXH2 2/20 0.35
MEN1 O00255 1/20 0.35
THRB P10828 1/20 0.35
ALOX15 P16050 1/20 0.35
GFER P55789 1/20 0.35
YWHAG P61981 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3627591 0.80 NPC1 (0.61) SIRT3TDP1CDC7CDK9NPC1
SCHEMBL16339823 0.79 MAPT (0.40) CHRM2CHRM3CHRM4PIM1PIM3
SCHEMBL883907 0.78 CDC7 (0.58) SIRT3TDP1CDC7CDK9NPC1
SCHEMBL14663533 0.77 PIM1 (0.51) SIRT3TDP1CDC7CDK9NPC1
SCHEMBL1068235 0.76 SIRT2 (0.35) SIRT3NPC1HTTCYP11B2CLK4
SCHEMBL2490477 0.73 NPC1 (0.42) NPC1KDM4EMEN1KMT2AHSD17B10
SCHEMBL2490932 0.72 CDC42BPB (0.42) CHRM1ROCK2
SCHEMBL29402739 0.70 SIRT3 (0.45) SIRT3TDP1CDC7CDK9NPC1
SCHEMBL17479788 0.70 HTT (0.43) CDC7CDK9NPC1HTTMAPT
SCHEMBL2489365 0.70 NPC1 (0.44) TDP1CDC7NPC1MEN1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3856183-A1 alfa2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA Bayer Aktiengesellschaft (DE) 2021-08-04 EP claimed
WO-2020064479-A1 α2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA BAYER AKTIENGESELLSCHAFT (DE) 2020-04-02 WO claimed
EP-2364303-A1 ARYL PIPERAZINE AND THEIR USE AS ALPHA2C ANTAGONISTS Orion Corporation (FI) 2011-09-14 EP claimed
WO-2010058060-A1 ARYL PIPERAZINE AND THEIR USE AS ALPHA2C ANTAGONISTS ORION CORPORATION (FI) 2010-05-27 WO claimed
EP-3856183-A1 alfa2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA Bayer Aktiengesellschaft (DE) 2021-08-04 EP disclosed
WO-2020064479-A1 α2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA BAYER AKTIENGESELLSCHAFT (DE) 2020-04-02 WO disclosed
EP-2364303-A1 ARYL PIPERAZINE AND THEIR USE AS ALPHA2C ANTAGONISTS Orion Corporation (FI) 2011-09-14 EP disclosed
WO-2010058060-A1 ARYL PIPERAZINE AND THEIR USE AS ALPHA2C ANTAGONISTS ORION CORPORATION (FI) 2010-05-27 WO disclosed