Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13365026 | 0.88 | KDM4E (0.50) | KDM4EMAPTPOLBKMT2ACYP1A2 | |
| SCHEMBL24757293 | 0.86 | KDM4E (0.49) | KDM4EMAPTPOLBKMT2ACYP1A2 | |
| SCHEMBL16617718 | 0.85 | KDM4E (0.52) | KDM4EMAPTPOLBKMT2ACYP1A2 | |
| SCHEMBL23112765 | 0.78 | KDM4E (0.47) | KDM4EMAPTPOLBKMT2ACYP1A2 | |
| SCHEMBL24758132 | 0.77 | KDM4E (0.49) | KDM4EMAPTPOLBKMT2ACYP1A2 | |
| SCHEMBL13682657 | 0.77 | KDM4E (0.49) | KDM4EMAPTPOLBKMT2ACYP1A2 | |
| SCHEMBL2363099 | 0.77 | KDM4E (0.49) | KDM4EMAPTPOLBKMT2ACYP1A2 | |
| SCHEMBL14487734 | 0.76 | KDM4E (0.48) | KDM4EMAPTPOLBKMT2ACYP1A2 | |
| SCHEMBL24906290 | 0.76 | KDM4E (0.48) | KDM4EMAPTPOLBKMT2ACYP1A2 | |
| SCHEMBL10717172 | 0.76 | KDM4E (0.48) | KDM4EMAPTPOLBKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | GRUENENTHAL GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025025-A1 | SUBSTITUTED PYRAZOLE AMIDES | SCN8A, SCN1A, SCN7A | KDM4E 2803/4885MAPT 2901/4885POLB 4395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.