Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489087 | 1.00 | PDE10A (1.00) | PDE10A | |
| SCHEMBL2488890 | 1.00 | PDE10A (1.00) | PDE10A | |
| SCHEMBL2488889 | 1.00 | PDE10A (1.00) | PDE10A | |
| SCHEMBL13332064 | 0.97 | PDE10A (1.00) | PDE10A | |
| SCHEMBL2489727 | 0.97 | PDE10A (1.00) | PDE10A | |
| SCHEMBL13332059 | 0.97 | PDE10A (1.00) | PDE10A | |
| SCHEMBL13332549 | 0.87 | PDE10A (1.00) | PDE10A | |
| SCHEMBL13332541 | 0.87 | PDE10A (1.00) | PDE10A | |
| SCHEMBL13332450 | 0.87 | PDE10A (1.00) | PDE10A | |
| SCHEMBL13332446 | 0.87 | PDE10A (1.00) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364306-A1 | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors | Amgen Inc. (US) | 2011-09-14 | — | — | EP | claimed |
| EP-2364306-A1 | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors | Amgen Inc. (US) | 2011-09-14 | — | — | EP | disclosed |