Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.45 |
| ▸ | ATRIP | Q8WXE1 | 4/20 | 0.45 |
| ▸ | MTOR | P42345 | 5/20 | 0.42 |
| ▸ | TAF1 | P21675 | 3/20 | 0.42 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4203309 | 0.91 | ATR (0.54) | ATRATRIPMTORTAF1PRKDC | |
| SCHEMBL2489919 | 0.90 | ATR (0.52) | ATRATRIPMTORTAF1PRKDC | |
| SCHEMBL6518645 | 0.90 | ATR (0.52) | ATRATRIPMTORTAF1PRKDC | |
| SCHEMBL4202234 | 0.90 | ATR (0.52) | ATRATRIPMTORTAF1PRKDC | |
| SCHEMBL2492774 | 0.89 | PIK3R1 (0.44) | ATRATRIPMTORTAF1PRKDC | |
| SCHEMBL6524143 | 0.89 | PIK3R1 (0.44) | ATRATRIPMTORTAF1PRKDC | |
| SCHEMBL4197531 | 0.88 | ATR (0.49) | ATRATRIPMTORTAF1PRKDC | |
| SCHEMBL2489905 | 0.88 | ATR (0.49) | ATRATRIPMTORTAF1PRKDC | |
| SCHEMBL2489908 | 0.88 | ATR (0.49) | ATRATRIPMTORTAF1PRKDC | |
| SCHEMBL2490413 | 0.88 | MTOR (0.50) | ATRATRIPMTORTAF1PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379530-A1 | PYRIMIDINE INDOLE DERIVATIVES FOR TREATING CANCER | AstraZeneca AB (SE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010073034-A1 | PYRIMIDINE INDOLE DERIVATIVES FOR TREATING CANCER | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | WO | disclosed |