Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | PANK3 | Q9H999 | 5/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17966630 | 0.85 | KDM4E (0.45) | KDM4EALDH1A1L3MBTL1IRAK4PANK3 | |
| SCHEMBL24908613 | 0.80 | NOTUM (0.41) | IRAK4PANK3CYP11B2CYP19A1CYP3A4 | |
| SCHEMBL23929971 | 0.77 | GRM5 (0.51) | KDM4EALDH1A1L3MBTL1IRAK4EGLN1 | |
| SCHEMBL22605742 | 0.77 | EGLN1 (0.47) | IRAK4EGLN1 | |
| SCHEMBL17394965 | 0.77 | KDM4E (0.49) | KDM4EALDH1A1L3MBTL1PANK3EGLN1 | |
| SCHEMBL18789238 | 0.77 | KDM4E (0.49) | KDM4EALDH1A1L3MBTL1IRAK4EGLN1 | |
| SCHEMBL23586654 | 0.75 | KDM4E (0.46) | KDM4EALDH1A1L3MBTL1PANK3EGLN1 | |
| SCHEMBL21491621 | 0.75 | KDM4E (0.46) | KDM4EALDH1A1L3MBTL1EGLN1GRM5 | |
| SCHEMBL21775949 | 0.74 | EGLN1 (0.41) | ALDH1A1IRAK4EGLN1 | |
| SCHEMBL17966629 | 0.73 | KDM4E (0.45) | KDM4EALDH1A1L3MBTL1PANK3EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230014445-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | LOXO ONCOLOGY, INC. | 2023-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014445-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PIK3CA, PIK3R4, PIK3R5 | KDM4E 2710/4885ALDH1A1 3272/4885L3MBTL1 2863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.