Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643339 | 0.81 | HTT (0.51) | HTTBDKRB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL644083 | 0.79 | BDKRB1 (0.49) | HTTBDKRB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL642965 | 0.78 | HTT (0.49) | HTTBDKRB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL643120 | 0.76 | HTT (0.47) | HTTBDKRB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL644293 | 0.75 | HTT (0.74) | HTTBDKRB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL642993 | 0.71 | BDKRB1 (0.54) | HTTBDKRB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL643338 | 0.69 | HTT (1.00) | HTTBDKRB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL643302 | 0.69 | BDKRB1 (0.55) | HTTBDKRB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL645135 | 0.68 | HTT (0.51) | HTTBDKRB1ALDH1A1KMT2AMEN1 | |
| SCHEMBL644127 | 0.68 | HTT (0.53) | HTTBDKRB1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | claimed |