Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 6/20 | 0.35 |
| ▸ | PAICS | P22234 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490991 | 1.00 | KDM4E (0.36) | KDM4EATMMAPTMAPK1CTSA | |
| SCHEMBL2490997 | 1.00 | KDM4E (0.36) | KDM4EATMMAPTMAPK1CTSA | |
| Hydrochloric Acid SCHEMBL544462 | 0.99 | KDM4E (0.36) | KDM4EATMMAPTMAPK1CTSA | |
| SCHEMBL914403 | 0.94 | CTSA (0.35) | KDM4EATMMAPTMAPK1CTSA | |
| SCHEMBL914407 | 0.94 | CTSA (0.35) | KDM4EATMMAPTMAPK1CTSA | |
| SCHEMBL914405 | 0.94 | CTSA (0.35) | KDM4EATMMAPTMAPK1CTSA | |
| Hydrochloric Acid SCHEMBL544075 | 0.94 | KDM4E (0.37) | KDM4EATMMAPTMAPK1CTSA | |
| Hydrochloric Acid SCHEMBL545050 | 0.94 | KDM4E (0.36) | KDM4EATMMAPTMAPK1CTSA | |
| Hydrochloric Acid SCHEMBL544864 | 0.94 | KDM4E (0.37) | KDM4EATMMAPTMAPK1CTSA | |
| Hydrochloric Acid SCHEMBL545060 | 0.93 | CTSA (0.34) | KDM4EATMMAPTMAPK1CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238110-B1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI SA (FR) | 2011-10-26 | — | — | EP | claimed |
| EP-2238110-B1 | 5.6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS ANTAGONISTS FOR UROTENSINE II RECEPTORS | SANOFI SA (FR) | 2011-10-26 | — | — | EP | disclosed |