Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | TEK | Q02763 | 2/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | TIE1 | P35590 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24917117 | 0.93 | PTK6 (0.44) | MAPKAPK5EGFRPTK6TTKAURKA | |
| SCHEMBL22124591 | 0.92 | MAPKAPK5 (0.41) | MAPKAPK5MAPK1FYNFLT1FLT4 | |
| SCHEMBL30349964 | 0.92 | MAPKAPK5 (0.41) | MAPKAPK5MAPK1FYNFLT1FLT4 | |
| SCHEMBL22124685 | 0.92 | MAPKAPK5 (0.40) | MAPKAPK5MAPK1JAK3RETPTK6 | |
| SCHEMBL22124669 | 0.92 | MAPKAPK5 (0.40) | MAPKAPK5MAPK1AXLKDRPTK6 | |
| SCHEMBL22125014 | 0.91 | MAPKAPK5 (0.42) | MAPKAPK5CD274FYNEGFRPTK6 | |
| SCHEMBL30349738 | 0.91 | MAPKAPK5 (0.42) | MAPKAPK5CD274FYNEGFRPTK6 | |
| SCHEMBL22124676 | 0.91 | TTK (0.39) | MAPKAPK5MAPK1AXLPTK6TTK | |
| SCHEMBL22124850 | 0.91 | MAPKAPK5 (0.41) | MAPKAPK5MAPK1KDRPTK6TTK | |
| SCHEMBL25170323 | 0.88 | MAPKAPK5 (0.40) | MAPKAPK5PTK6TTKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230017532-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230017532-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, O60361, MYD88 | MAPKAPK5 695/4885MAPK1 320/4885CD274 3787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.