⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1445474 | 0.72 | — | — | |
| SCHEMBL2023689 | 0.69 | — | — | |
| SCHEMBL8498999 | 0.69 | — | — | |
| SCHEMBL4430993 | 0.65 | — | — | |
| SCHEMBL9749128 | 0.63 | — | — | |
| SCHEMBL4163472 | 0.63 | — | — | |
| SCHEMBL31691655 | 0.63 | — | — | |
| SCHEMBL4501254 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL3523504 | 0.62 | KDM4E (0.33) | — | |
| SCHEMBL2351188 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190040001-A1 | METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA | PARATEK PHARMACEUTICALS, INC. | 2019-02-07 | — | — | US | disclosed |
| US-9562003-B2 | Methods of using substituted tetracycline compounds to modulate RNA | PARATEK PHARMACEUTICALS, INC. (US) | 2017-02-07 | — | — | US | disclosed |
| US-20160324880-A1 | 4-DEDIMETHYLAMINO TETRACYCLINE COMPOUNDS | PARATEK PHARMACEUTICALS, INC. | 2016-11-10 | — | — | US | disclosed |
| EP-2995610-A1 | 4-DEDIMETHYLAMINO TETRACYCLINE COMPOUNDS | Paratek Pharmaceuticals, Inc. (US) | 2016-03-16 | — | — | EP | disclosed |
| US-9278911-B2 | 4-dedimethylamino tetracycline compounds | PARATEK PHARMACEUTICALS, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-20150321997-A1 | METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA | PARATEK PHARMACEUTICALS, INC. (US) | 2015-11-12 | — | — | US | disclosed |
| EP-2322501-B1 | 4-dedimethylamino tetracycline compounds | PARATEK PHARM INNC (US) | 2015-08-05 | — | — | EP | disclosed |
| US-20150105355-A1 | 4-DEDIMETHYLAMINO TETRACYCLINE COMPOUNDS | PARATEK PHARMACEUTICALS, INC. (US) | 2015-04-16 | — | — | US | disclosed |
| US-20140343020-A1 | METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA | PARATEK PHARMACEUTICALS, INC (US) | 2014-11-20 | — | — | US | disclosed |
| US-8492365-B2 | 7-substituted tetracycline compounds | TRUSTEES OF TUFTS COLLEGE (US) | 2013-07-23 | — | — | US | disclosed |
| US-20040092490-A1 | Substituted tetracycline compounds for the treatment of malaria | PARATEK PHARMACEUTICALS, INC. | 2004-05-13 | — | — | US | disclosed |
| WO-2004038001-A2 | SUBSTITUTED TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF MALARIA | PARATEK PHARMACEUTICALS, INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| WO-2004038000-A2 | METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA | PARATEK PHARMACEUTICALS, INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| EP-1399414-A2 | SUBSTITUTED TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF MALARIA | Paratek Pharmaceuticals, Inc. (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003079984-A2 | SUBSTITUTED TETRACYCLINE COMPOUNDS | PARATEK PHARMACEUTICALS, INC. (US) | 2003-10-02 | — | — | WO | disclosed |
| WO-2003057169-A2 | 4-DEDIMETHYLAMINO TETRACYCLINE COMPOUNDS | PARATEK PHARMACEUTICALS, INC. (US) | 2003-07-17 | — | — | WO | disclosed |
| EP-1301466-A2 | 7-SUBSTITUTED TETRACYCLINE COMPOUNDS | TRUSTEES OF TUFTS COLLEGE (US) | 2003-04-16 | — | — | EP | disclosed |
| US-20030055025-A1 | 7-substituted tetracycline compounds | PARATEK PHARMACEUTICALS, INC. | 2003-03-20 | — | — | US | disclosed |
| WO-2002085303-A2 | SUBSTITUTED TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF MALARIA | PARATEK PHARMACEUTICALS, INC. (US) | 2002-10-31 | — | — | WO | disclosed |
| WO-2002004407-A2 | 7-SUBSTITUTED TETRACYCLINE COMPOUNDS | TRUSTEES OF TUFTS COLLEGE (US) | 2002-01-17 | — | — | WO | disclosed |