Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.67 |
| ▸ | JAK1 | P23458 | 7/20 | 0.67 |
| ▸ | JAK3 | P52333 | 6/20 | 0.66 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.66 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228200 | 0.95 | JAK2 (0.69) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL7977613 | 0.89 | JAK2 (0.69) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL7974880 | 0.86 | JAK2 (0.74) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL2144298 | 0.86 | JAK2 (0.55) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL13072885 | 0.84 | JAK2 (0.76) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL7975705 | 0.84 | JAK2 (0.76) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL13033022 | 0.83 | JAK2 (0.79) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL7963261 | 0.83 | JAK2 (0.71) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL13276297 | 0.83 | JAK2 (0.66) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL13072782 | 0.83 | JAK2 (0.74) | JAK2JAK1JAK3PTK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609098-B1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-07-13 | — | — | EP | disclosed |
| WO-2012025186-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |