SCHEMBL24925293

SCHEMBL24925293

Cc1ccc(C(=O)Nc2cnn(C(C)(C)C)c2)cc1C#Cc1cccnc1

nearest known ligand 0.65

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 1/20 0.65
KIT P10721 17/20 0.61
ABL1 P00519 1/20 0.55
DDR1 Q08345 13/20 0.53
DDR2 Q16832 2/20 0.52
NPC1 O15118 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29602539 1.00 CSF1R (0.65) CSF1RKITABL1DDR1DDR2
SCHEMBL22833530 0.86 CSF1R (0.61) CSF1RKITABL1DDR1DDR2
SCHEMBL22833839 0.85 CSF1R (0.65) CSF1RKITABL1DDR1DDR2
SCHEMBL29506321 0.85 CSF1R (0.65) CSF1RKITABL1DDR1DDR2
SCHEMBL22833926 0.84 CSF1R (0.64) CSF1RKITABL1DDR1DDR2
SCHEMBL22833516 0.84 CSF1R (0.61) CSF1RKITABL1DDR1DDR2
SCHEMBL24925721 0.83 CSF1R (0.62) CSF1RKITABL1DDR1DDR2
SCHEMBL22833536 0.83 CSF1R (0.62) CSF1RKITABL1DDR1DDR2
SCHEMBL29506239 0.83 CSF1R (0.62) CSF1RKITABL1DDR1DDR2
SCHEMBL22833523 0.83 CSF1R (0.59) CSF1RKITABL1DDR1DDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230014226-A1 NEW COMPOUNDS AND METHODS BENEVOLENTAI BIO LIMITED (GB) 2023-01-19 US claimed
EP-3986559-A1 NEW COMPOUNDS AND METHODS BenevolentAI Bio Limited (GB) 2022-04-27 EP claimed
CN-114340734-A Novel compounds and methods 博善人工智能生物科技有限公司 2022-04-12 CN claimed
WO-2020260871-A1 NEW COMPOUNDS AND METHODS BENEVOLENTAI BIO LIMITED (GB) 2020-12-30 WO claimed
US-20230014226-A1 NEW COMPOUNDS AND METHODS BENEVOLENTAI BIO LIMITED (GB) 2023-01-19 US disclosed
US-20230014226-A1 NEW COMPOUNDS AND METHODS BENEVOLENTAI BIO LIMITED (GB) 2023-01-19 US disclosed
EP-3986559-A1 NEW COMPOUNDS AND METHODS BenevolentAI Bio Limited (GB) 2022-04-27 EP disclosed
CN-114340734-A Novel compounds and methods 博善人工智能生物科技有限公司 2022-04-12 CN disclosed
WO-2020260871-A1 NEW COMPOUNDS AND METHODS BENEVOLENTAI BIO LIMITED (GB) 2020-12-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230014226-A1 NEW COMPOUNDS AND METHODS ABL2, ABL1, ALK CSF1R 4175/4885KIT 457/4885ABL1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.