Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.78 |
| ▸ | ALB | P02768 | 1/20 | 0.78 |
| ▸ | MAOA | P21397 | 1/20 | 0.78 |
| ▸ | CNR1 | P21554 | 1/20 | 0.78 |
| ▸ | DRD1 | P21728 | 1/20 | 0.78 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.78 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tafamidis SCHEMBL442508 | 0.87 | TTR (1.00) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL30049107 | 0.87 | TTR (0.80) | TTRALBMAOACNR1DRD1 | |
| Tafamidis SCHEMBL29361223 | 0.87 | TTR (1.00) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL23703798 | 0.87 | TTR (0.80) | TTRALBMAOACNR1DRD1 | |
| Tafamidis SCHEMBL25398819 | 0.86 | TTR (0.97) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL16208751 | 0.86 | TTR (0.78) | TTRALBMAOACNR1DRD1 | |
| Tafamidis SCHEMBL22529633 | 0.85 | TTR (0.76) | TTRALBMAOACNR1DRD1 | |
| Tafamidis SCHEMBL22529630 | 0.85 | TTR (0.76) | TTRALBMAOACNR1DRD1 | |
| Tafamidis SCHEMBL30543503 | 0.83 | TTR (0.85) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL23729105 | 0.83 | TTR (0.72) | TTRALBMAOACNR1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009585-A2 | TRANSTHYRETIN STABILIZING COMPOUNDS | PROTEGO BIOPHARMA, INC. (US) | 2023-02-02 | — | — | WO | disclosed |