Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.79 |
| ▸ | STAT6 | P42226 | 11/20 | 0.76 |
| ▸ | CCNK | O75909 | 1/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | CCND3 | P30281 | 1/20 | 0.60 |
| ▸ | CDK9 | P50750 | 1/20 | 0.60 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736067 | 0.88 | SYK (1.00) | SYKSTAT6 | |
| SCHEMBL2389021 | 0.87 | STAT6 (0.77) | SYKSTAT6 | |
| SCHEMBL2386576 | 0.84 | STAT6 (1.00) | SYKSTAT6 | |
| SCHEMBL736688 | 0.83 | SYK (1.00) | SYK | |
| SCHEMBL2386837 | 0.83 | STAT6 (1.00) | SYKSTAT6 | |
| SCHEMBL2386908 | 0.81 | STAT6 (0.85) | SYKSTAT6 | |
| SCHEMBL23200452 | 0.81 | CDK2 (0.80) | SYKCCNKCCNA2CDK2CCND3 | |
| SCHEMBL2386532 | 0.81 | STAT6 (0.77) | SYKSTAT6 | |
| Hydrochloric Acid SCHEMBL2385626 | 0.80 | STAT6 (0.80) | SYKSTAT6 | |
| SCHEMBL15161255 | 0.80 | SYK (0.84) | SYKSTAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1518855-B1 | DIAMINOPYRIMIDINECARBOXA MIDE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2011-10-26 | — | — | EP | disclosed |
| US-7449456-B2 | Diaminopyrimidinecarboxamide derivative | ASTELLAS PHARMA, INC. (JP) | 2008-11-11 | — | — | US | disclosed |