Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.72 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.72 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.72 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.72 |
| ▸ | FLT3 | P36888 | 1/20 | 0.72 |
| ▸ | BLK | P51451 | 1/20 | 0.72 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.72 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.72 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29632307 | 0.88 | CHEK1 (0.87) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL24945094 | 0.88 | CHEK1 (0.87) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL24485498 | 0.87 | CHEK1 (0.79) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| Hydrochloric Acid SCHEMBL26668648 | 0.87 | CHEK1 (0.85) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| Prexasertib SCHEMBL18955240 | 0.84 | CHEK1 (0.96) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL24936228 | 0.84 | CHEK1 (1.00) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| Prexasertib SCHEMBL30528862 | 0.84 | CHEK1 (1.00) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| Prexasertib SCHEMBL30517001 | 0.84 | CHEK1 (1.00) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| Prexasertib SCHEMBL1975451 | 0.84 | CHEK1 (1.00) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| Prexasertib SCHEMBL29371799 | 0.84 | CHEK1 (1.00) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025065-A1 | 5-HETEROARYL-1H-PYRAZOL-3-AMINE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025065-A1 | 5-HETEROARYL-1H-PYRAZOL-3-AMINE DERIVATIVE | CHEK1, CHEK2, RB1 | CHEK1 1/4885KCNH2 2700/4885NUAK1 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.