Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 18/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | TSPO | P30536 | 1/20 | 0.66 |
| ▸ | DNER | Q8NFT8 | 2/20 | 0.65 |
| ▸ | BRDT | Q58F21 | 8/20 | 0.63 |
| ▸ | BRD2 | P25440 | 3/20 | 0.63 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.63 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
| ▸ | BRD1 | O95696 | 1/20 | 0.63 |
| ▸ | CCL2 | P13500 | 1/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.63 |
| ▸ | EP300 | Q09472 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24391065 | 1.00 | BRD4 (0.74) | BRD4ADORA3TSPODNERBRDT | |
| SCHEMBL19627341 | 0.91 | BRD4 (0.89) | BRD4ADORA3TSPODNERBRDT | |
| SCHEMBL18628050 | 0.91 | BRD4 (0.89) | BRD4ADORA3TSPODNERBRDT | |
| SCHEMBL19627343 | 0.91 | BRD4 (0.89) | BRD4ADORA3TSPODNERBRDT | |
| SCHEMBL24938243 | 0.90 | BRD4 (0.81) | BRD4ADORA3TSPODNERBRDT | |
| SCHEMBL24391070 | 0.90 | BRD4 (0.81) | BRD4ADORA3TSPODNERBRDT | |
| SCHEMBL20827382 | 0.89 | BRD4 (0.75) | BRD4ADORA3TSPODNERBRDT | |
| SCHEMBL24391068 | 0.88 | BRD4 (0.83) | BRD4ADORA3TSPODNERBRDT | |
| SCHEMBL19630937 | 0.85 | BRD4 (1.00) | BRD4ADORA3TSPODNERBRDT | |
| SCHEMBL19627339 | 0.85 | BRD4 (1.00) | BRD4ADORA3TSPODNERBRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256470-B1 | METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES | DANA FARBER CANCER INST INC (US) | 2023-07-26 | — | — | EP | disclosed |
| EP-4119552-A1 | REGULATING CHIMERIC ANTIGEN RECEPTORS | Dana-Farber Cancer Institute, Inc. (US) | 2023-01-18 | — | — | EP | disclosed |