Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.72 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.72 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.72 |
| ▸ | STAT6 | P42226 | 6/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2385618 | 0.99 | SYK (0.71) | SYKAURKBKCNH2ZAP70STAT6 | |
| SCHEMBL10243575 | 0.94 | SYK (0.72) | SYKAURKBKCNH2ZAP70STAT6 | |
| SCHEMBL764094 | 0.92 | SYK (0.67) | SYKAURKBKCNH2ZAP70STAT6 | |
| SCHEMBL2387743 | 0.91 | STAT6 (0.70) | SYKAURKBKCNH2ZAP70STAT6 | |
| SCHEMBL2388956 | 0.91 | SYK (0.66) | SYKAURKBKCNH2ZAP70STAT6 | |
| SCHEMBL23752202 | 0.91 | SYK (0.66) | SYKAURKBKCNH2ZAP70STAT6 | |
| SCHEMBL4713716 | 0.91 | SYK (0.66) | SYKAURKBKCNH2ZAP70STAT6 | |
| SCHEMBL29644953 | 0.91 | SYK (0.66) | SYKAURKBKCNH2ZAP70STAT6 | |
| SCHEMBL10241903 | 0.90 | SYK (0.70) | SYKAURKBKCNH2ZAP70STAT6 | |
| SCHEMBL14659023 | 0.90 | SYK (0.72) | SYKAURKBKCNH2ZAP70STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1518855-B1 | DIAMINOPYRIMIDINECARBOXA MIDE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2011-10-26 | — | — | EP | disclosed |
| EP-1054004-B1 | NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2008-07-16 | — | — | EP | disclosed |
| US-6432963-B1 | ANTIINFLAMMATORY AGENTS; TYROSINE KINASE INHIBITOR | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1054004-A1 | NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-11-22 | — | — | EP | disclosed |