Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30908047 | 0.85 | MAPT (0.43) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL27410904 | 0.81 | MAPT (0.46) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL30908011 | 0.78 | CRBN (0.41) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL27410907 | 0.73 | CRBN (0.43) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL24939662 | 0.71 | CRBN (0.43) | MAPTHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL30908036 | 0.71 | AR (0.44) | MAPTHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL27410927 | 0.71 | AR (0.44) | MAPTHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL27411344 | 0.70 | AR (0.47) | CRBN | |
| SCHEMBL27410891 | 0.70 | AR (0.47) | CRBN | |
| SCHEMBL31485008 | 0.69 | CA1 (0.44) | HTTHDAC1HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001028-A1 | HETEROARYL-3-PIPERIDINEDIONE COMPOUND AND USE THEREOF | 南京明德新药研发有限公司 | 2023-01-26 | — | — | WO | disclosed |