Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.32 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | NIM1K | Q8IY84 | 1/20 | 0.30 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205542 | 1.00 | LRRK2 (0.38) | LRRK2IKBKETBK1ULK3MKNK2 | |
| SCHEMBL24944207 | 0.94 | LRRK2 (0.37) | LRRK2IKBKETBK1ULK3MKNK2 | |
| SCHEMBL29173293 | 0.94 | LRRK2 (0.37) | LRRK2IKBKETBK1ULK3MKNK2 | |
| SCHEMBL24944208 | 0.94 | LRRK2 (0.37) | LRRK2IKBKETBK1ULK3MKNK2 | |
| SCHEMBL30205523 | 0.94 | LRRK2 (0.37) | LRRK2IKBKETBK1ULK3MKNK2 | |
| SCHEMBL29173311 | 0.93 | LRRK2 (0.37) | LRRK2IKBKETBK1ULK3MKNK2 | |
| SCHEMBL30206245 | 0.92 | LRRK2 (0.35) | LRRK2IKBKETBK1ULK3MKNK2 | |
| SCHEMBL24944553 | 0.90 | LRRK2 (0.42) | LRRK2IKBKETBK1ULK3MKNK2 | |
| SCHEMBL24944425 | 0.89 | LRRK2 (0.36) | LRRK2MAP3K14 | |
| SCHEMBL30205549 | 0.89 | LRRK2 (0.36) | LRRK2MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |