Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206173 | 1.00 | LRRK2 (0.35) | LRRK2EGFRKCNH2PDCD1CD274 | |
| SCHEMBL31195405 | 0.94 | LRRK2 (0.36) | LRRK2EGFRKCNH2PDCD1CD274 | |
| Formic Acid SCHEMBL30206024 | 0.91 | PIK3CG (0.35) | LRRK2EGFRKCNH2PDCD1CD274 | |
| SCHEMBL30205495 | 0.90 | LRRK2 (0.36) | LRRK2EGFRKCNH2MOKJAK2 | |
| SCHEMBL24944784 | 0.90 | LRRK2 (0.36) | LRRK2EGFRKCNH2MOKJAK2 | |
| SCHEMBL24944993 | 0.88 | LRRK2 (0.40) | LRRK2EGFRKCNH2CSF1RJAK2 | |
| SCHEMBL29173704 | 0.84 | LRRK2 (0.36) | LRRK2EGFRKCNH2PDCD1CD274 | |
| SCHEMBL30206132 | 0.84 | LRRK2 (0.36) | LRRK2EGFRKCNH2PDCD1CD274 | |
| SCHEMBL30206021 | 0.82 | LRRK2 (0.40) | LRRK2EGFRKCNH2CSF1RJAK2 | |
| SCHEMBL29173398 | 0.82 | LRRK2 (0.40) | LRRK2EGFRKCNH2CSF1RJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |