Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefixime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 1.00 |
| ▸ | APEX1 | P27695 | 3/20 | 1.00 |
| ▸ | APAF1 | O14727 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | PLCG1 | P19174 | 1/20 | 1.00 |
| ▸ | ABCC2 | Q92887 | 1/20 | 1.00 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 1.00 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.98 |
| ▸ | MMP2 | P08253 | 1/20 | 0.98 |
| ▸ | MAPT | P10636 | 4/20 | 0.79 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.79 |
| ▸ | CNR1 | P21554 | 1/20 | 0.79 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.79 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | PPARG | P37231 | 2/20 | 0.61 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.61 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefixime SCHEMBL3553111 | 1.00 | TDP1 (1.00) | TDP1APEX1APAF1LMNAL3MBTL1 | |
| Cefixime SCHEMBL4812946 | 1.00 | TDP1 (1.00) | TDP1APEX1APAF1LMNAL3MBTL1 | |
| Cefixime SCHEMBL17131963 | 1.00 | TDP1 (1.00) | TDP1APEX1APAF1LMNAL3MBTL1 | |
| Cefixime SCHEMBL16072825 | 1.00 | TDP1 (1.00) | TDP1APEX1APAF1LMNAL3MBTL1 | |
| Cefixime SCHEMBL9483204 | 1.00 | TDP1 (1.00) | TDP1APEX1APAF1LMNAL3MBTL1 | |
| Cefixime SCHEMBL12374914 | 1.00 | TDP1 (1.00) | TDP1APEX1APAF1LMNAL3MBTL1 | |
| Cefixime SCHEMBL3553107 | 1.00 | TDP1 (1.00) | TDP1APEX1APAF1LMNAL3MBTL1 | |
| Cefixime SCHEMBL4812929 | 1.00 | TDP1 (1.00) | TDP1APEX1APAF1LMNAL3MBTL1 | |
| Cefixime SCHEMBL9483213 | 1.00 | TDP1 (1.00) | TDP1APEX1APAF1LMNAL3MBTL1 | |
| Cefixime SCHEMBL49534 | 1.00 | TDP1 (1.00) | TDP1APEX1APAF1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 30895 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12637481-B2 | Boronic acid derivatives and therapeutic uses thereof | QPEX BIOPHARMA, INC. (US) | 2026-05-26 | — | — | US | claimed |
| CN-122079926-A | Preparation method of cefixime side chain acid active ester with stable quality | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026104587-A1 | CYCLIC BORONIC ACID ESTERS USEFUL AS ADJUVANTS IN THE TREATMENT OF BACTERIAL INFECTIONS | ADJUTEC PHARMA AS (NO) | 2026-05-21 | — | — | WO | claimed |
| CN-115215923-B | Macrocyclic broad-spectrum antibiotics | 豪夫迈·罗氏有限公司 | 2026-05-19 | — | — | CN | claimed |
| EP-4740962-A1 | PHARMACEUTICAL COMPOSITION, FORMULATION CONTAINING PHARMACEUTICAL COMPOSITION, KIT CONTAINING PHARMACEUTICAL COMPOSITION, PREPARATION METHOD FOR PHARMACEUTICAL COMPOSITION, AND USE OF PHARMACEUTICAL COMPOSITION | Shanghai WD Pharmaceutical Co., Ltd (CN) | 2026-05-13 | — | — | EP | claimed |
| EP-4739326-A2 | PRODUCTION & SECRETION OF AUXIN-LIKE MOLECULES IN BACTERIA | SNIPR Biome ApS (DK) | 2026-05-13 | — | — | EP | claimed |
| EP-4735619-A1 | REACTION MEDIUM AND METHOD FOR DETECTING SHIGA TOXIN-PRODUCING E.COLI AND/OR ENTEROHAEMORRHAGIC E.COLI | BIOMERIEUX (FR) | 2026-05-06 | — | — | EP | claimed |
| US-20260115234-A1 | PRODUCTION & SECRETION OF AUXIN-LIKE MOLECULES IN BACTERIA | SNIPR BIOME APS (DK) | 2026-04-30 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| EP-0680322-A1 | PHARMACEUTICAL FORMULATIONS COMPRISING CLAVULANIC ACID ALONE OR IN COMBINATION WITH OTHER BETA-LACTAM ANTIBIOTICS | SMITHKLINE BEECHAM PLC (GB) | 1995-11-08 | — | — | EP | claimed |
| US-5464616-A | Antibiotic enzyme inhibitors and kits | SYNPHAR LABORATORIES, IND. (CA) | 1995-11-07 | — | — | US | claimed |
| EP-0678095-A1 | CRYSTALLINE PENICILLIN DERIVATIVE, AND ITS PRODUCTION AND USE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1995-10-25 | — | — | EP | claimed |
| WO-1995012601-A1 | CRYSTALLINE PENICILLIN DERIVATIVE, AND ITS PRODUCTION AND USE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1995-05-11 | — | — | WO | claimed |
| US-5409917-A | Topical treatment of acne with cephalosporins | Towsend, Marvin S. (US) | 1995-04-25 | — | — | US | claimed |
| WO-1995000527-A1 | FUCOSYLATED GLYCOSIDES AS INHIBITORS OF BACTERIAL ADHERENCE | ASTRA AKTIEBOLAG (SE) | 1995-01-05 | — | — | WO | claimed |
| WO-1994016696-A1 | PHARMACEUTICAL FORMULATIONS COMPRISING CLAVULANIC ACID ALONE OR IN COMBINATION WITH OTHER BETA-LACTAM ANTIBIOTICS | SMITHKLINE BEECHAM PLC (GB) | 1994-08-04 | — | — | WO | claimed |
| EP-0568200-A2 | Pharmaceutical and foodstuff compositions containing transferrius and antibacteral agents for potentiating host defense activity and the treatment of infections | IMMUNO JAPAN INC. (JP) | 1993-11-03 | — | — | EP | claimed |
| EP-0530311-A1 | THE USE OF PHENYLPROPANOLAMINE AS A MUCUS SECRETAGOGUE IN THE UPPER AIRWAYS | Norwich-Eaton Pharmaceuticals, Inc. (US) | 1993-03-10 | — | — | EP | claimed |
| WO-1991017746-A1 | THE USE OF PHENYLPROPANOLAMINE AS A MUCUS SECRETAGOGUE IN THE UPPER AIRWAYS | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1991-11-28 | — | — | WO | claimed |