Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 15/20 | 0.67 |
| ▸ | CA2 | P00918 | 15/20 | 0.67 |
| ▸ | CA9 | Q16790 | 13/20 | 0.67 |
| ▸ | CA12 | O43570 | 4/20 | 0.67 |
| ▸ | CA7 | P43166 | 4/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.67 |
| ▸ | CA3 | P07451 | 3/20 | 0.67 |
| ▸ | CA4 | P22748 | 3/20 | 0.67 |
| ▸ | CA6 | P23280 | 3/20 | 0.67 |
| ▸ | CA5A | P35218 | 3/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL148280 | 1.00 | CA1 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL3354 | 1.00 | CA1 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL41458 | 1.00 | CA1 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL17336090 | 1.00 | CA1 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL474049 | 1.00 | CA1 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL771183 | 1.00 | CA1 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL143596 | 1.00 | CA1 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL42396 | 1.00 | CA1 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL147679 | 1.00 | CA1 (0.67) | CA1CA2CA9CA12CA7 | |
| SCHEMBL5199618 | 1.00 | CA1 (0.67) | CA1CA2CA9CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9393242-B2 | Compositions for treatment of ear disorders and methods of use thereof | OTIC PHARMA LTD. (IL) | 2016-07-19 | — | — | US | disclosed |
| EP-1699431-B1 | COMPOSITIONS FOR TREATMENT OF EAR DISORDERS AND METHODS OF USE THEREOF | OTIC PHARMA LTD (IL) | 2015-08-19 | — | — | EP | disclosed |
| US-8940321-B2 | Compositions for treatment of ear disorders and methods of use thereof | OTIC PHARMA LTD. (IL) | 2015-01-27 | — | — | US | disclosed |
| US-20120252720-A1 | COMPOSITIONS FOR TREATMENT OF EAR DISORDERS AND METHODS OF USE THEREOF | OTIC PHARMA LTD. (IL) | 2012-10-04 | — | — | US | disclosed |
| US-8030362-B2 | Admixing a pharmaceutical agent with a foam forming agent; introducing the mixture of into a dispensing device; metered dose, external auditory meatus | OTIC PHARMA LTD. (IL) | 2011-10-04 | — | — | US | disclosed |
| US-20080075670-A1 | Compositions for Treatment of Ear Disorders and Methods of Use Thereof | OTIC PHARMA LTD. (IL) | 2008-03-27 | — | — | US | disclosed |
| EP-1699431-A2 | COMPOSITIONS FOR TREATMENT OF EAR DISORDERS AND METHODS OF USE THEREOF | Eilat, Eran (IL) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005055921-A2 | COMPOSITIONS FOR TREATMENT OF EAR DISORDERS AND METHODS OF USE THEREOF | EILAT ERAN (IL) | 2005-06-23 | — | — | WO | disclosed |