SCHEMBL24949575

SCHEMBL24949575

O=C1CCC(n2nnc3cc4ccccc4cc32)C(=O)N1

nearest known ligand 0.60

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 19/20 0.60
DDB1 Q16531 17/20 0.60
IKZF3 Q9UKT9 4/20 0.51
ALDH1A1 P00352 1/20 0.48
CHRM2 P08172 1/20 0.48
OPRM1 P35372 1/20 0.48
CYP1A2 P05177 1/20 0.48
TSHR P16473 1/20 0.48
TDP1 Q9NUW8 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24948829 0.85 CRBN (0.61) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL25653897 0.81 CRBN (0.52) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL31426262 0.81 CRBN (0.52) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL31425845 0.81 CRBN (0.52) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL31444718 0.81 CRBN (0.65) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL25653883 0.81 CRBN (0.52) CRBNDDB1IKZF3ALDH1A1TSHR
SCHEMBL23065980 0.81 CRBN (0.48) CRBNDDB1IKZF3ALDH1A1TSHR
SCHEMBL23566317 0.81 CRBN (0.48) CRBNDDB1IKZF3ALDH1A1CHRM2
Hydrochloric Acid SCHEMBL31520634 0.80 CRBN (0.63) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL24938736 0.80 CRBN (0.57) CRBNDDB1IKZF3ALDH1A1CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230158152-A1 PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME MEDSHINE DISCOVERY INC. (CN) 2023-05-25 US disclosed
EP-4122925-A1 PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME Medshine Discovery Inc. (CN) 2023-01-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230158152-A1 PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME PSMA6, PSMC1, PSMA1 CRBN 111/4885DDB1 2308/4885IKZF3 640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.