Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21719183 | 0.98 | TLR8 (0.30) | TLR8 | |
| SCHEMBL22065925 | 0.93 | TLR8 (0.32) | TLR8KCNH2CNR2 | |
| SCHEMBL20049876 | 0.82 | TLR8 (0.43) | TLR8 | |
| SCHEMBL21719187 | 0.82 | KCNH2 (0.32) | TLR8KCNH2CNR2 | |
| SCHEMBL21719179 | 0.81 | TLR8 (0.30) | TLR8 | |
| SCHEMBL21719076 | 0.81 | AR (0.32) | TLR8 | |
| SCHEMBL21719180 | 0.78 | TLR8 (0.31) | TLR8CNR2 | |
| SCHEMBL24951899 | 0.77 | TLR8 (0.31) | TLR8KCNH2CNR2 | |
| SCHEMBL19618116 | 0.76 | TLR8 (0.45) | TLR8 | |
| SCHEMBL26850422 | 0.75 | KCNH2 (0.34) | TLR8KCNH2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230027257-A1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | KANION USA INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230027257-A1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | PARP1, PARP2, PARP11 | TLR8 1294/4885KCNH2 4478/4885CNR2 2410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.