Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.42 |
| ▸ | SGK1 | O00141 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24954492 | 1.00 | MAP4K1 (0.63) | MAP4K1PIK3CGCAMKK2SGK1AXL | |
| Hydrochloric Acid SCHEMBL29216546 | 0.99 | MAP4K1 (0.62) | MAP4K1PIK3CGCAMKK2SGK1AXL | |
| Hydrochloric Acid SCHEMBL30215923 | 0.99 | MAP4K1 (0.62) | MAP4K1PIK3CGCAMKK2SGK1AXL | |
| Hydrochloric Acid SCHEMBL29216545 | 0.99 | MAP4K1 (0.62) | MAP4K1PIK3CGCAMKK2SGK1AXL | |
| SCHEMBL24954312 | 0.86 | MAP4K1 (0.68) | MAP4K1PIK3CGDYRK1B | |
| SCHEMBL24954311 | 0.86 | MAP4K1 (0.68) | MAP4K1PIK3CGDYRK1B | |
| Hydrochloric Acid SCHEMBL29216544 | 0.86 | MAP4K1 (0.67) | MAP4K1PIK3CGDYRK1B | |
| Hydrochloric Acid SCHEMBL30215925 | 0.86 | MAP4K1 (0.67) | MAP4K1PIK3CGDYRK1B | |
| Hydrochloric Acid SCHEMBL29216543 | 0.86 | MAP4K1 (0.67) | MAP4K1PIK3CGDYRK1B | |
| SCHEMBL24955735 | 0.83 | MAP4K1 (0.63) | MAP4K1PIK3CGCAMKK2MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006063-A1 | PYRROLO [2, 3-b] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-02-02 | — | — | WO | disclosed |