Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604308 | 1.00 | CYP1A2 (0.49) | CYP1A2POLBCYP3A4CYP2C19CHRM2 | |
| SCHEMBL2499441 | 1.00 | CYP1A2 (0.49) | CYP1A2POLBCYP3A4CYP2C19CHRM2 | |
| SCHEMBL2493129 | 1.00 | CYP1A2 (0.49) | CYP1A2POLBCYP3A4CYP2C19CHRM2 | |
| SCHEMBL4488887 | 1.00 | CYP1A2 (0.49) | CYP1A2POLBCYP3A4CYP2C19CHRM2 | |
| SCHEMBL30955475 | 0.89 | CYP1A2 (0.42) | CYP1A2POLBCYP3A4CYP2C19CHRM2 | |
| SCHEMBL25836938 | 0.88 | CHRM2 (0.40) | CYP1A2POLBCYP3A4CYP2C19CHRM2 | |
| SCHEMBL25836961 | 0.88 | CHRM2 (0.40) | CYP1A2POLBCYP3A4CYP2C19CHRM2 | |
| SCHEMBL25177825 | 0.87 | CYP1A2 (0.46) | CYP1A2POLBCYP3A4CYP2C19CHRM2 | |
| SCHEMBL31340622 | 0.87 | CYP1A2 (0.46) | CYP1A2POLBCYP3A4CYP2C19CHRM2 | |
| SCHEMBL8135313 | 0.87 | CYP1A2 (0.46) | CYP1A2POLBCYP3A4CYP2C19CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |