Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 14/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.73 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.73 |
| ▸ | PLK4 | O00444 | 2/20 | 0.73 |
| ▸ | ABL1 | P00519 | 2/20 | 0.73 |
| ▸ | LCK | P06239 | 2/20 | 0.73 |
| ▸ | CSF1R | P07333 | 2/20 | 0.73 |
| ▸ | RET | P07949 | 2/20 | 0.73 |
| ▸ | KIT | P10721 | 2/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.73 |
| ▸ | SRC | P12931 | 2/20 | 0.73 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.73 |
| ▸ | TYK2 | P29597 | 2/20 | 0.73 |
| ▸ | KDR | P35968 | 2/20 | 0.73 |
| ▸ | FLT3 | P36888 | 2/20 | 0.73 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.73 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.73 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.73 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12038579 | 1.00 | AURKA (0.73) | AURKAAURKBNTRK1PLK4ABL1 | |
| SCHEMBL2495654 | 1.00 | AURKA (0.73) | AURKAAURKBNTRK1PLK4ABL1 | |
| SCHEMBL2495206 | 0.99 | AURKA (0.75) | AURKAAURKBNTRK1PLK4ABL1 | |
| SCHEMBL2495205 | 0.99 | AURKA (0.75) | AURKAAURKBNTRK1PLK4ABL1 | |
| SCHEMBL2501336 | 0.95 | AURKA (0.68) | AURKAAURKBNTRK1PLK4ABL1 | |
| SCHEMBL12057596 | 0.95 | AURKA (0.68) | AURKAAURKBNTRK1PLK4ABL1 | |
| SCHEMBL2501332 | 0.95 | AURKA (0.68) | AURKAAURKBNTRK1PLK4ABL1 | |
| SCHEMBL2499575 | 0.93 | AURKA (0.76) | AURKAAURKBNTRK1PLK4ABL1 | |
| SCHEMBL2499576 | 0.93 | AURKA (0.76) | AURKAAURKBNTRK1PLK4ABL1 | |
| SCHEMBL9988837 | 0.92 | AURKA (0.72) | AURKAAURKBNTRK1PLK4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110318393-A1 | Substituted Pyrazole Compounds | MIIKANA THERAPEUTICS, INC. (US) | 2011-12-29 | — | — | US | disclosed |
| EP-2373313-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS | Miikana Therapeutics, Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010062848-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIKANA THERAPEUTICS, INC. (US) | 2010-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110318393-A1 | Substituted Pyrazole Compounds | AURKA, AURKC, AURKB | AURKA 1/4885AURKB 3/4885NTRK1 1683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.