Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21811202 | 0.84 | TYK2 (0.60) | TYK2STAT3MEN1KMT2APDE4D | |
| SCHEMBL30349550 | 0.84 | TYK2 (0.60) | TYK2STAT3MEN1KMT2APDE4D | |
| SCHEMBL21887788 | 0.82 | TYK2 (0.53) | TYK2TP53STAT3HPGDPDE4D | |
| SCHEMBL21887360 | 0.76 | TYK2 (0.52) | TYK2STAT3PDE4D | |
| SCHEMBL24961646 | 0.75 | TYK2 (0.51) | TYK2STAT3PDE4D | |
| SCHEMBL21811191 | 0.74 | TYK2 (0.61) | TYK2STAT3HPGDPDE4DALDH1A1 | |
| SCHEMBL30349558 | 0.74 | TYK2 (0.61) | TYK2STAT3HPGDPDE4DALDH1A1 | |
| SCHEMBL24961657 | 0.73 | TYK2 (0.55) | TYK2STAT3MAPK10GAAPDE4D | |
| SCHEMBL21887515 | 0.73 | TYK2 (0.84) | TYK2STAT3PDE4D | |
| SCHEMBL21811321 | 0.73 | TYK2 (0.84) | TYK2STAT3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849981-B1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | LILLY CO ELI (US) | 2023-02-01 | — | — | EP | disclosed |