Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20292872 | 1.00 | DYRK1A (0.55) | DYRK1ADYRK1BROCK1CDC42BPBROCK2 | |
| SCHEMBL24967755 | 0.95 | DYRK1A (0.53) | DYRK1ADYRK1BPDE10ACDC7BTK | |
| SCHEMBL20292968 | 0.95 | DYRK1A (0.53) | DYRK1ADYRK1BPDE10ACDC7BTK | |
| SCHEMBL20292862 | 0.88 | DYRK1A (0.62) | DYRK1ADYRK1BROCK1CDC42BPBROCK2 | |
| SCHEMBL20293037 | 0.83 | DYRK1A (0.59) | DYRK1ADYRK1BROCK1CDC42BPBCDC7 | |
| SCHEMBL2185869 | 0.81 | MAP4K4 (0.47) | AURKAPDPK1AURKBMAP4K4PDE10A | |
| SCHEMBL2185867 | 0.81 | MAP4K4 (0.47) | AURKAPDPK1AURKBMAP4K4PDE10A | |
| Trifluoromethanesulfonic Acid SCHEMBL27824179 | 0.81 | SYK (0.46) | AURKAPDPK1AURKBMAP4K4PDE10A | |
| SCHEMBL2185107 | 0.80 | MAP4K4 (0.52) | AURKAPDPK1AURKBMAP4K4PDE10A | |
| SCHEMBL2185110 | 0.80 | MAP4K4 (0.52) | AURKAPDPK1AURKBMAP4K4PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558321-B1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS INC (US) | 2023-02-01 | — | — | EP | disclosed |