Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | CTSC | P53634 | 4/20 | 0.36 |
| ▸ | GLI1 | P08151 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2495777 | 1.00 | DPP4 (0.37) | DPP4CTSCGLI1SMYD3CHEK1 | |
| Trifluoroacetic Acid SCHEMBL2495230 | 1.00 | DPP4 (0.37) | DPP4CTSCGLI1SMYD3CHEK1 | |
| Trifluoroacetic Acid SCHEMBL4486156 | 1.00 | DPP4 (0.37) | DPP4CTSCGLI1SMYD3CHEK1 | |
| SCHEMBL2501849 | 0.90 | DPP4 (0.42) | DPP4CTSCGLI1SMYD3CHEK1 | |
| SCHEMBL13868126 | 0.90 | DPP4 (0.42) | DPP4CTSCGLI1SMYD3CHEK1 | |
| Hydrochloric Acid SCHEMBL1465647 | 0.88 | DPP4 (0.41) | DPP4CTSCGLI1SMYD3CHEK1 | |
| Trifluoroacetic Acid SCHEMBL2494834 | 0.84 | DPP4 (0.37) | DPP4CTSCGLI1SMYD3CHEK1 | |
| Trifluoroacetic Acid SCHEMBL2496511 | 0.84 | DPP4 (0.37) | DPP4CTSCGLI1SMYD3CHEK1 | |
| Trifluoroacetic Acid SCHEMBL2497613 | 0.84 | DPP4 (0.37) | DPP4CTSCGLI1SMYD3CHEK1 | |
| Trifluoroacetic Acid SCHEMBL2493610 | 0.84 | DPP4 (0.37) | DPP4CTSCGLI1SMYD3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |
| US-7528124-B2 | 1,3-dihydro-2H-indol-2-one derivative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-05-05 | — | — | US | disclosed |
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-25 | — | — | US | disclosed |
| US-20060276449-A1 | 1,3-Dihydro-2h-indol-2-one derivative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2006-12-07 | — | — | US | disclosed |
| EP-1659121-A1 | 1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-05-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276449-A1 | 1,3-Dihydro-2h-indol-2-one derivative | AVPR1B, AVPR2, AVPR1A | DPP4 2321/4885CTSC 1896/4885GLI1 1252/4885 |
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | AVPR1B, AVPR1A, AVPR2 | DPP4 2704/4885CTSC 1030/4885GLI1 561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.