Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 8/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26301 | 0.91 | SMYD3 (0.71) | SMYD3HDAC3HDAC1HDAC6PDGFRA | |
| SCHEMBL29528307 | 0.81 | SMYD3 (0.59) | SMYD3HDAC3HDAC1CRBNHDAC6 | |
| SCHEMBL23175705 | 0.78 | HDAC2 (0.58) | SMYD3HDAC3HDAC1CRBNHDAC6 | |
| SCHEMBL5316057 | 0.76 | CRBN (0.81) | SMYD3HDAC3HDAC1CRBNHDAC6 | |
| SCHEMBL4935353 | 0.76 | SMYD3 (0.74) | SMYD3HDAC3HDAC1HDAC6HDAC4 | |
| SCHEMBL29899620 | 0.75 | SMYD3 (0.54) | SMYD3 | |
| SCHEMBL23143521 | 0.75 | SMYD3 (0.54) | SMYD3 | |
| SCHEMBL3207365 | 0.75 | SMYD3 (0.72) | SMYD3HDAC3HDAC1HDAC6HDAC4 | |
| SCHEMBL18006544 | 0.74 | EPHX2 (0.54) | SMYD3HDAC3HDAC1CRBNHDAC6 | |
| SCHEMBL3182105 | 0.74 | SMYD3 (0.71) | SMYD3HDAC3HDAC1HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025726-A1 | Novel Hybrid Compounds | UNIVERSITY OF GREENWICH (GB) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012025726-A1 | Novel Hybrid Compounds | UNIVERSITY OF GREENWICH (GB) | 2012-03-01 | — | — | WO | disclosed |