Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | KIT | P10721 | 4/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31557817 | 1.00 | FLT3 (0.59) | FLT3MAPK8IRAK4KDRKIT | |
| SCHEMBL31557786 | 0.92 | FLT3 (0.54) | FLT3MAPK8IRAK4KDRKIT | |
| SCHEMBL24975706 | 0.92 | FLT3 (0.54) | FLT3MAPK8IRAK4KDRKIT | |
| SCHEMBL24231275 | 0.90 | FLT3 (0.48) | FLT3MAPK8IRAK4KDRKIT | |
| SCHEMBL30248551 | 0.90 | FLT3 (0.48) | FLT3MAPK8IRAK4KDRKIT | |
| SCHEMBL24975662 | 0.89 | FLT3 (0.47) | FLT3MAPK8IRAK4KDRKIT | |
| SCHEMBL31557797 | 0.89 | FLT3 (0.47) | FLT3MAPK8IRAK4KDRKIT | |
| SCHEMBL31557789 | 0.89 | FLT3 (0.47) | FLT3MAPK8IRAK4KDRKIT | |
| SCHEMBL24975665 | 0.89 | FLT3 (0.47) | FLT3MAPK8IRAK4KDRKIT | |
| SCHEMBL24975667 | 0.88 | FLT3 (0.45) | FLT3MAPK8IRAK4KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |