Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 9/20 | 0.39 |
| ▸ | NRAS | P01111 | 4/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 4/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.38 |
| ▸ | CDK7 | P50613 | 4/20 | 0.37 |
| ▸ | CCNH | P51946 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 3/20 | 0.37 |
| ▸ | RET | P07949 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CCNK | O75909 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31557809 | 1.00 | IRAK4 (0.44) | IRAK4MAPK8FLT3NRASIRAK1 | |
| SCHEMBL27362416 | 1.00 | IRAK4 (0.44) | IRAK4MAPK8FLT3NRASIRAK1 | |
| SCHEMBL27362512 | 1.00 | IRAK4 (0.44) | IRAK4MAPK8FLT3NRASIRAK1 | |
| SCHEMBL31557791 | 0.92 | IRAK4 (0.40) | IRAK4MAPK8FLT3NRASMAPK9 | |
| SCHEMBL24976678 | 0.92 | IRAK4 (0.40) | IRAK4MAPK8FLT3NRASMAPK9 | |
| SCHEMBL31068078 | 0.90 | IRAK4 (0.49) | IRAK4FLT3NRASIRAK1CDK7 | |
| SCHEMBL24574000 | 0.90 | IRAK4 (0.49) | IRAK4FLT3NRASIRAK1CDK7 | |
| SCHEMBL27362525 | 0.90 | IRAK4 (0.49) | IRAK4FLT3NRASIRAK1CDK7 | |
| SCHEMBL24975875 | 0.86 | FLT3 (0.38) | IRAK4FLT3NRASIRAK1CDK7 | |
| SCHEMBL31557810 | 0.86 | FLT3 (0.38) | IRAK4FLT3NRASIRAK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |