Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.41 |
| ▸ | NRAS | P01111 | 11/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.40 |
| ▸ | CDK7 | P50613 | 3/20 | 0.40 |
| ▸ | CCNH | P51946 | 3/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CCNK | O75909 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31557816 | 1.00 | FLT3 (0.41) | FLT3NRASIRAK4CDK7CCNH | |
| SCHEMBL27362507 | 1.00 | FLT3 (0.41) | FLT3NRASIRAK4CDK7CCNH | |
| SCHEMBL31000099 | 0.94 | IRAK4 (0.38) | FLT3NRASIRAK4CDK7CCNH | |
| SCHEMBL31557787 | 0.93 | FLT3 (0.37) | FLT3NRASIRAK4CDK7CCNH | |
| SCHEMBL24975656 | 0.93 | FLT3 (0.37) | FLT3NRASIRAK4CDK7CCNH | |
| SCHEMBL31000184 | 0.93 | FLT3 (0.39) | FLT3NRASIRAK4CDK7CCNH | |
| SCHEMBL31000202 | 0.91 | FLT3 (0.38) | FLT3NRASIRAK4CDK7CCNH | |
| SCHEMBL31000143 | 0.91 | FLT3 (0.41) | FLT3NRASIRAK4CDK7CCNH | |
| SCHEMBL31000204 | 0.89 | MAPK8 (0.38) | FLT3NRASIRAK4CDK7CCNH | |
| SCHEMBL24975652 | 0.88 | FLT3 (0.51) | FLT3NRASIRAK4CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030908-A1 | MULTI-CYCLIC IRAK1 AND IRAK4 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |