Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.53 |
| ▸ | FLT3 | P36888 | 12/20 | 0.52 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | CCNH | P51946 | 2/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.47 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.47 |
| ▸ | NRAS | P01111 | 7/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24231303 | 0.91 | FLT3 (0.54) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL24976035 | 0.91 | FLT3 (0.54) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL24975937 | 0.90 | IRAK4 (0.51) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL10239487 | 0.89 | FLT3 (0.51) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL376164 | 0.89 | FLT3 (0.66) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL24976585 | 0.88 | IRAK4 (0.55) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL10238387 | 0.88 | FLT3 (0.53) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL24975940 | 0.86 | FLT3 (0.46) | IRAK4FLT3NRASCSF1RKDR | |
| SCHEMBL24977195 | 0.86 | FLT3 (0.56) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL10239843 | 0.85 | FLT3 (0.51) | IRAK4FLT3IRAK1LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250154144-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDRENS HOSPITAL MED CT (US) | 2025-05-15 | — | — | US | disclosed |
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250154144-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | FLT3, IRAK1, IRAK3 | IRAK4 5/4885FLT3 1/4885IRAK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.