Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 17/20 | 0.57 |
| ▸ | NRAS | P01111 | 14/20 | 0.57 |
| ▸ | IRAK1 | P51617 | 5/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.54 |
| ▸ | CDK7 | P50613 | 3/20 | 0.54 |
| ▸ | CCNH | P51946 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24975710 | 0.95 | NRAS (0.53) | FLT3NRASIRAK1IRAK4PDGFRB | |
| SCHEMBL31557782 | 0.95 | NRAS (0.53) | FLT3NRASIRAK1IRAK4PDGFRB | |
| SCHEMBL24975889 | 0.90 | FLT3 (0.47) | FLT3NRASIRAK1IRAK4PDGFRB | |
| SCHEMBL24232069 | 0.88 | FLT3 (0.74) | FLT3NRASIRAK1IRAK4PDGFRB | |
| SCHEMBL31557798 | 0.87 | NRAS (0.56) | FLT3NRASIRAK1IRAK4PDGFRB | |
| SCHEMBL24976239 | 0.87 | NRAS (0.56) | FLT3NRASIRAK1IRAK4PDGFRB | |
| SCHEMBL30248471 | 0.86 | FLT3 (0.41) | FLT3NRASIRAK1IRAK4PDGFRB | |
| SCHEMBL24975945 | 0.86 | FLT3 (0.41) | FLT3NRASIRAK1IRAK4PDGFRB | |
| SCHEMBL24975687 | 0.86 | FLT3 (0.58) | FLT3NRASIRAK1IRAK4PDGFRB | |
| SCHEMBL24977200 | 0.83 | FLT3 (0.49) | FLT3NRASIRAK1IRAK4PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |