Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.54 |
| ▸ | FLT3 | P36888 | 7/20 | 0.54 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | CDK7 | P50613 | 1/20 | 0.54 |
| ▸ | BLK | P51451 | 1/20 | 0.54 |
| ▸ | CCNH | P51946 | 1/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.51 |
| ▸ | NRAS | P01111 | 4/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31557781 | 1.00 | IRAK4 (0.54) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL31000113 | 0.91 | IRAK4 (0.51) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL10239892 | 0.85 | FLT3 (0.57) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL31557799 | 0.84 | IRAK4 (0.47) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL24976238 | 0.84 | IRAK4 (0.47) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL24975877 | 0.83 | FLT3 (0.49) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL24977161 | 0.83 | FLT3 (0.49) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL24976668 | 0.83 | FLT3 (0.49) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL30248481 | 0.83 | FLT3 (0.49) | IRAK4FLT3IRAK1LCKRET | |
| SCHEMBL31557798 | 0.83 | NRAS (0.56) | IRAK4FLT3IRAK1LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A9 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |