Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 14/20 | 0.38 |
| ▸ | NRAS | P01111 | 4/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24976678 | 0.81 | IRAK4 (0.40) | IRAK4MAPK8MAPK9MAPK10JUN | |
| SCHEMBL31557791 | 0.81 | IRAK4 (0.40) | IRAK4MAPK8MAPK9MAPK10JUN | |
| SCHEMBL24977165 | 0.81 | IRAK4 (0.52) | IRAK4MAPK8MAPK9MAPK10JUN | |
| SCHEMBL31557784 | 0.81 | MAPK8 (0.43) | IRAK4MAPK8MAPK9MAPK10JUN | |
| SCHEMBL24975946 | 0.81 | MAPK8 (0.43) | IRAK4MAPK8MAPK9MAPK10JUN | |
| SCHEMBL27368889 | 0.78 | FLT3 (0.53) | IRAK4FLT3NRASIRAK1 | |
| SCHEMBL24573956 | 0.78 | FLT3 (0.53) | IRAK4FLT3NRASIRAK1 | |
| SCHEMBL30248551 | 0.78 | FLT3 (0.48) | IRAK4MAPK8MAPK9MAPK10JUN | |
| SCHEMBL24231275 | 0.78 | FLT3 (0.48) | IRAK4MAPK8MAPK9MAPK10JUN | |
| SCHEMBL24976680 | 0.77 | IRAK4 (0.39) | IRAK4MAPK8MAPK9MAPK10JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009833-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-02-02 | — | — | WO | disclosed |