Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 14/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.36 |
| ▸ | TTK | P33981 | 3/20 | 0.35 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 6/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24939258 | 0.93 | PTK6 (0.41) | PTK6AURKBTTKMAPKAPK5LCK | |
| SCHEMBL22124078 | 0.90 | PTK6 (0.43) | PTK6AURKBTTKMAPKAPK5LCK | |
| SCHEMBL24870761 | 0.89 | PTK6 (0.40) | PTK6AURKBTTKMAPKAPK5LCK | |
| SCHEMBL22124292 | 0.89 | PTK6 (0.40) | PTK6AURKBTTKMAPKAPK5LCK | |
| Formic Acid SCHEMBL25171886 | 0.88 | PTK6 (0.39) | PTK6AURKBTTKMAPKAPK5LCK | |
| SCHEMBL24910616 | 0.86 | PTK6 (0.44) | PTK6AURKBTTKMAPKAPK5LCK | |
| SCHEMBL22123982 | 0.85 | PTK6 (0.44) | PTK6AURKBTTKMAPKAPK5LCK | |
| SCHEMBL24977802 | 0.84 | PTK6 (0.43) | PTK6AURKBTTKLCK | |
| SCHEMBL24978617 | 0.84 | PTK6 (0.43) | PTK6AURKBTTKLCK | |
| SCHEMBL24978331 | 0.84 | PTK6 (0.43) | PTK6AURKBTTKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230022724-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230022724-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, O60361, MYD88 | PTK6 2201/4885AURKB 3265/4885TTK 4546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.