Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.56 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | BLK | P51451 | 1/20 | 0.55 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.55 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.55 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23327503 | 0.89 | CHEK1 (0.62) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL23327328 | 0.84 | CHEK1 (0.61) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL23327289 | 0.83 | CHEK1 (0.57) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL27858284 | 0.82 | CHEK1 (0.52) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL24978462 | 0.81 | CHEK1 (0.56) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL19243743 | 0.81 | CHEK1 (0.64) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL30101613 | 0.81 | CHEK1 (0.64) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL23327341 | 0.81 | CHEK1 (0.62) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL23327373 | 0.81 | CHEK1 (0.62) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL23327268 | 0.80 | CHEK1 (0.61) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230310423-A1 | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | BOUNDLESS BIO, INC. | 2023-10-05 | — | — | US | disclosed |
| US-20230310423-A1 | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | BOUNDLESS BIO, INC. | 2023-10-05 | — | — | US | disclosed |
| US-11707462-B2 | Checkpoint kinase 1 (CHK1) inhibitors and uses thereof | BOUNDLESS BIO, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-11707462-B2 | Checkpoint kinase 1 (CHK1) inhibitors and uses thereof | BOUNDLESS BIO, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-20230026313-A1 | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | BOUNDLESS BIO, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230310423-A1 | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | CHEK1, CHEK2, RAD1 | CHEK1 1/4885KCNH2 4493/4885NUAK1 189/4885 |
| US-11707462-B2 | Checkpoint kinase 1 (CHK1) inhibitors and uses thereof | CHEK1, CHEK2, RAD1 | CHEK1 1/4885KCNH2 4493/4885NUAK1 189/4885 |
| US-20230026313-A1 | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | CHEK1, CHEK2, RAD1 | CHEK1 1/4885KCNH2 4493/4885NUAK1 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.