Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4579608 | 0.92 | PLK1 (0.76) | PLK1 | |
| SCHEMBL2523836 | 0.92 | PLK1 (0.78) | PLK1 | |
| SCHEMBL2516478 | 0.92 | PLK1 (0.80) | PLK1 | |
| SCHEMBL2521826 | 0.91 | PLK1 (0.79) | PLK1 | |
| SCHEMBL2523908 | 0.90 | PLK1 (0.76) | PLK1 | |
| SCHEMBL2518635 | 0.90 | PLK1 (0.76) | PLK1 | |
| SCHEMBL2526052 | 0.90 | PLK1 (0.78) | PLK1 | |
| SCHEMBL2518636 | 0.90 | PLK1 (0.76) | PLK1 | |
| SCHEMBL2526050 | 0.90 | PLK1 (0.78) | PLK1 | |
| SCHEMBL2523899 | 0.90 | PLK1 (0.76) | PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030327-B2 | 3-[1-(2-chlorophenyl)ethoxy]-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxyamide; polo like kinase inhibitor; antitumor and anticarcinogenic agent; mitotic phase (M phase) of the cell cycle | MDS K.K. (JP) | 2011-10-04 | — | — | US | disclosed |