Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 19/20 | 0.50 |
| ▸ | AVPR2 | P30518 | 6/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | OXTR | P30559 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2499494 | 1.00 | AVPR1A (0.50) | AVPR1AAVPR2KCNH2OXTR | |
| SCHEMBL2493203 | 0.92 | AVPR1A (0.58) | AVPR1AAVPR2KCNH2OXTR | |
| SCHEMBL2473593 | 0.92 | AVPR1A (0.58) | AVPR1AAVPR2KCNH2OXTR | |
| SCHEMBL2469540 | 0.92 | AVPR1A (0.58) | AVPR1AAVPR2KCNH2OXTR | |
| SCHEMBL3332125 | 0.92 | AVPR1A (0.58) | AVPR1AAVPR2KCNH2OXTR | |
| SCHEMBL2493200 | 0.92 | AVPR1A (0.58) | AVPR1AAVPR2KCNH2OXTR | |
| SCHEMBL12076805 | 0.90 | AVPR1A (0.52) | AVPR1AAVPR2KCNH2OXTR | |
| SCHEMBL12076804 | 0.90 | AVPR1A (0.52) | AVPR1AAVPR2KCNH2OXTR | |
| SCHEMBL12077160 | 0.90 | AVPR1A (0.52) | AVPR1AAVPR2KCNH2OXTR | |
| SCHEMBL12077159 | 0.90 | AVPR1A (0.52) | AVPR1AAVPR2KCNH2OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461152-B2 | Arylcyclohexylethers of dihydrotetraazabenzoazulenes | HOFFMANN-LA ROCHE INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20120225865-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES | SCHNIDER PATRICK (CH) | 2012-09-06 | — | — | US | disclosed |
| EP-2370441-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010060836-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES FOR USE AS VASOPRESSIN VIA RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225865-A1 | ARYLCYCLOHEXYLETHERS OF DIHYDROTETRAAZABENZOAZULENES | AVPR1A, AVPR1B, AVPR2 | AVPR1A 1/4885AVPR2 3/4885KCNH2 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.