Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25001983 | 0.89 | EGFR (0.57) | EGFRBTKMAP4K1ALKCDK19 | |
| SCHEMBL25001849 | 0.88 | EGFR (0.57) | EGFRBTKMAP4K1 | |
| SCHEMBL25002404 | 0.85 | EGFR (0.49) | EGFRBTKMAP4K1ALKCDK19 | |
| SCHEMBL23442867 | 0.83 | EGFR (0.47) | EGFRBTKTTK | |
| SCHEMBL25001851 | 0.80 | EGFR (0.40) | EGFRMAP4K1ALKLRRK2 | |
| SCHEMBL25002078 | 0.78 | EGFR (0.60) | EGFRBTK | |
| SCHEMBL25002079 | 0.78 | EGFR (0.60) | EGFRBTK | |
| SCHEMBL25001573 | 0.78 | EGFR (0.60) | EGFRBTK | |
| SCHEMBL23441794 | 0.78 | EGFR (0.60) | EGFRBTK | |
| SCHEMBL25001789 | 0.78 | EGFR (0.69) | EGFRBTKMAP4K1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4129996-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-02-08 | — | — | EP | disclosed |