Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.56 |
| ▸ | BTK | Q06187 | 2/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.47 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25001554 | 0.89 | EGFR (0.68) | EGFRBTKALKCDK19MAP4K1 | |
| SCHEMBL25001558 | 0.89 | EGFR (0.55) | EGFRBTKALKCDK19MAP4K1 | |
| SCHEMBL25002762 | 0.82 | EGFR (0.65) | EGFRBTKALKCDK19MAP4K1 | |
| SCHEMBL25820625 | 0.82 | EGFR (0.62) | EGFR | |
| SCHEMBL25827271 | 0.82 | EGFR (0.52) | EGFRBTK | |
| SCHEMBL25001456 | 0.82 | EGFR (0.49) | EGFR | |
| SCHEMBL25821109 | 0.80 | EGFR (0.49) | EGFR | |
| SCHEMBL25001951 | 0.79 | EGFR (0.66) | EGFRBTKALKCDK19MAP4K1 | |
| SCHEMBL25001794 | 0.78 | EGFR (0.84) | EGFRBTKALKMAP4K1 | |
| SCHEMBL25001489 | 0.78 | EGFR (0.84) | EGFRBTKALKCDK19TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4129996-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-02-08 | — | — | EP | disclosed |